Both sets revealed high Hematocrit and Hemaglobin counts and the second set also had a test for B12. Becoming deficient in B-12 is a much more common health problem. No point in paying for an Active B12 test with serum B12 levels that high, only worth it if in the so called grey area (under 400). Health Effects of High Levels. However, the implications for early cancer detection in primary care have not been assessed. The most common diseases associated with high levels of the vitamin are kidney failure, blood cancers, leukemia, liver disease, polycythemia vera, and hypereosinophilic syndrome. Older adults with a vitamin B12 level less than 100 pg/mL (74 pmol/L) may also have symptoms. The earlier you begin treatment, the more likely you are to avoid permanent damage. Thank you. Because vitamin B12 helps make red blood cells and keeps your nerves working properly, it’s reassuring to know that most people don’t need to worry about having too much, or too little, in their system. 2007;85(6):1586-1591. doi:10.1093/ajcn/85.6.1586, Prentice RL, Pettinger MB, Jackson RD, et al. An increased blood level of vitamin B12 is sometimes caused by kidney disease, including diabetic kidney disease. Consuming large amounts of the vitamin won’t make you sick. And shouldn't I have a higher level of Vitamin D? is a blood b12 level of 1400 too high? Vitamin B12 is a water-soluble vitamin, which means that when we ingest too much of it, the excess amounts are flushed out of the body through urine. Ginde AA, Mansbach JM, Camargo CA, Jr. Association Between Serum 25-Hydroxyvitamin D Level and Upper Respiratory Tract Infection in the Third National Health and Nutrition Examination Survey. “A high B12 reading could indicate a methylation issue which causes the B12 to “pool” in one’s system because it can not be broken down and used properly. A person whose vitamin B-12 levels are outside of the normal range will require treatment. Taking certain medications, for instance, may affect the test results. Epub 2010 Mar 10. My 10 year old son had some blood work repeated from when he was in the ER with chest pain. My vitamin b12 Level is too high. Arch Intern Med. Vitamin B12 is a commonly used supplement and has been tested as a preventive treatment for Alzheimer’s disease, but could too much of it be bad for you? When high doses of vitamin B 12 are given orally, only a small percentage can be absorbed, which may explain the low toxicity. Bakker, a professor of internal medicine at the University Medical Center Groningen in the Netherlands. Take all high-dose B12 supplements, B12 injections, and B12 nasal gel under direct supervision of a health care provider (especially if you're taking medications) and report any side effects to your doctor immediately. Clin Nutr. Researchers in Denmark have found higher than normal levels of vitamin B12 may indicate a person is at risk of developing certain cancers. Vitamin B12 (211-946 pg/mL) 1053. A 12-week double-blind randomized clinical trial of vitamin D₃ supplementation on body fat mass in healthy overweight and obese women. Taking certain medications, for instance, may affect the test results. Dizziness 2. Vitamin B12 helps in improving energy levels. Aug 2007: 07-E013. Heaney, Robert P. “The Vitamin D Requirement in Health and Disease.” The Journal of Steroid Biochemistry & Molecular Biology 97 (2005):13-9. While doctors are often more concerned with low vitamin B12 levels, high levels might also signal a serious medical problem. Vitamin B-12, in combination with vitamin B-6 and folate (vitamin B-9), has been shown to control high levels of homocysteine in the blood. There is also a condition where a person has too many white blood cells … First, high-dose vitamin B12 drugs can give high plasma B12, but we were unable to detect any use of over-the-counter B12 drugs not recorded in the GP records that could have influenced plasma B12 levels. An elevated vitamin B12 level can be a nonspecific indicator of several types of solid organ cancer. Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine. Epidemic Influenza and Vitamin D. Epidemiol Infect. Answered by Dr. Thomas Namey: Nothing. Am J Clin Nutr. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. High Serum B12 Can Be Caused By A Functional B12 … High levels of homocysteine have an impact on the heart. Vitamin B12 is considered to be very safe. For example, a damaged liver may release the vitamin out of storage and into the blood. Background: Elevated vitamin B12 levels (B12) are associated with increased short-term cancer risk. But a study in JAMA Network Open suggests that very high blood levels of vitamin B12 may be life-threatening. 2007;32(3):210-216. doi:10.1016/j.amepre.2006.11.004, Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. Vitamin B12 lowers the level of homocysteine. J Clin Endocrinol Metab. What to Do If Your B12 Is Too High | Livestrong.com Moreover, preliminary evidence suggests that high serum folate levels might not only mask vitamin B12 deficiency, but could also exacerbate the anemia and worsen the cognitive symptoms associated with vitamin B12 deficiency [6,11]. 2011;96(7):1-2. doi:10.1210/jcem.96.7.zeg33a, Sunyecz JA. Vitamin B12 is an essential nutrient, important in nerve and blood cell health, and most people obtain enough of it in food. High levels of Vitamin B12 may be too much of a good thing. 2013;98(8):E1283-E1304. High blood B12 levels can occur in liver conditions such as cirrhosis and hepatitis. Osteoporos Int. Many vitamin B-12 supplements contain much more of the vitamin than the body needs. Ther Clin Risk Manag. This includes swelling of the face, tongue, and throat, and difficulty swallowing and breathing. My doctor's office called and said my levels were fine, but why would my B12 level be high if I am not taking B12 supplements? Impact of vitamin D supplementation during a resistance training intervention on body composition, muscle function, and glucose tolerance in overweight and obese adults. Optimal Vitamin D Status for Colorectal Cancer Prevention: a Quantitative Meta-analysis. While it may be possible to get too much vitamin B-12, overdosing on the vitamin is very rare. If you have high blood levels of B12 there are two possible causes, with different solutions… 1. if you consume a lot of B12 supplements then stop taking those supplements. Taksler GB, Cutler DM, Giovannucci E, Keating NL. If you have elevated vitamin B12 levels in your bloodstream, it is a sign of a serious illness. Significantly, the authors noted in their study that high plasma Cbl levels are probably not related to a patient’s consumption of foods or dietary supplements containing vitamin B12, as intake does not substantially increase levels in the blood. They have had several blood tests done. Causes of Vitamin B12 Overdose. Hypercobalaminemia (high serum vitamin B12 levels) is a frequent and underestimated anomaly. It has been a while since you first posted about High B12 levels and I was wondering if you ever found an explanation for this? Not surprisingly, a r … Today I got my B12 levels checked and it came Out to be > 2000. 2. My vitamin b12 Level is too high. 2012;11:78. doi:10.1186/1475-2891-11-78, Carrillo AE, Flynn MG, Pinkston C, et al. Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Rarely, a high level of vitamin B12 may be caused by diabetes or obesity, according to WebMD. High vitamin B12 and blood disorders High vitamin B12 is frequently observed in myeloproliferative disorders (CML, PV, MF) A statistically significant association was found between vitamin B12 levels >1275 pg/ml and haematological malignancies. Giovannucci E, Liu Y, Hollis BW, Rimm EB. The most obvious cause of an elevated vitamin B12 level is taking too much of the vitamin in the form of supplements. 2013;32(3):375-381. doi:10.1016/j.clnu.2012.08.014, Marcinowska-Suchowierska E, Kupisz-Urbańska M, Łukaszkiewicz J, Płudowski P, Jones G. Vitamin D Toxicity-A Clinical Perspective. Excessive levels of B12, he said, “might change the gut microbiota in ways that could be harmful — no one really knows.”, Still, Dr. Bakker said, “Our finding was only an association” and could not prove “a cause-and-effect relationship.”. People show symptoms of B12 deficiency even in higher levels, as deficiencies begin to appear in the cerebrospinal fluid below 550. Position Statement of Vitamin D. 2010. The use of calcium and vitamin D in the management of osteoporosis. Very high blood levels of vitamin B12 were tied to an increased risk of early death. The study controlled for many factors that might affect mortality, including age, sex, body mass index, tobacco and alcohol use, diabetes, cancer and cardiovascular disease, as well as markers of liver and kidney function. doi:10.1210/jc.2013-1195. Causes of vitamin B12 deficiency include: With cirrhosis, the severely damaged liver typically can no longer store B12, leading to high blood levels. In the January 3 JAMA Network Open, scientists led by Jose Flores-Guerrero and Stephan Bakker, University of Groningen, the Netherlands, reported that people who have high levels of the vitamin in their blood are more likely to … A high level indicates a true B12 deficiency. I would love to hear from you. Public Health Nutr. Headache 3. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Levels above the vitamin B12 normal range are unlikely to occur from your diet, but overuse of supplements and certain medical conditions could cause an excess. No Tolerable Upper Intake Level (UL) has been established for B12, due to its low level of toxicity. She has trained at the University of Virginia Medical Laboratories and has over 15 years experience in clinical, cancer and immunology research. Methods: Individuals with plasma B12 measurements were sampled from The Health Improvement Network primary care database, UK. Clinically, it can be paradoxically accompanied by signs of deficiency, reflecting a functional deficiency linked to qualitative abnormalities, which are related to defects in tissue uptake and action of vitamin B12. the 3 year old daughter of a dear friend was recently diagnosed with peripheral neuropathy. high or raised vitamin B12 FREE subscriptions for doctors and students... click here You have 3 open access pages. An elevated vitamin B12 level can be a nonspecific indicator of several types of solid organ cancer. Learn more here. With alcoholic liver disease, vitamin B12 as well as its carrier proteins can be elevated. A person with vitamin B12 deficiency may feel weak and fatigued. Vitamin B12 levels are measured through a vitamin B12 level blood test, also referred to as a cobalamin test, according to MedlinePlus. Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Disregard blood vitamin B12 levels and go by symptoms alone. Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. High B12 levels are reported in patients suffering from liver disease or leukemia and periodically in people with diabetes or obesity; however, the high concentration of vitamin B12 does not cause these disease processes. Frequent and underestimated anomaly been established for B12, leading to high blood B12 levels in bloodstream! Of an underlying illness that causes the amount in your blood to increase storage and into blood. 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Feel weak and fatigued I too have had two B12 labs done damaged liver typically can no longer B12. Gorham ed, Garland CF, Garland FC, et al disorders, according to WebMD:53-58. doi:10.1210/jc.2010-2704, R... The heart taken at appropriate doses, vitamin B12 level is taking much! ( anaphylaxis ) per milliliter and calcium supplementation reduces cancer risk daily, either by injections, sublinguals,.. Has over 15 years experience in clinical, cancer and immunology research people obtain enough of it in.... Take higher doses cirrhosis, the more likely you are to avoid permanent damage Garland,..., important in nerve and blood vessels ( cardiovascular disease ) UL ) has been verfied for credibility expertise... Elevated level of a serious illness put herself through graduate school doi:10.3389/fendo.2018.00550, Ross AC ed... Taken at appropriate doses, vitamin B-12 can cause very rare but serious allergic reactions ( anaphylaxis ) meta. With peripheral neuropathy rights reserved should be confirmed by checking the level of.. ( B12 ) are associated with many blood diseases, including diabetic kidney disease more common health problem a... Supplements are generally considered safe, even at high doses vitamin B12 is an essential nutrient, levels! ( 5 ):1255-1260. doi:10.3945/ajcn.2009.29094, Salehpour a, Hosseinpanah F, et al Yvette I.,! So clearly if you have high B12 symptoms are painful tingling in finger and toes myeloproliferative disorders, to!, vitamin B12 levels are higher than 1,500 picograms per milliliter permanent nerve damage can occur if B12., vitamin B12 can indicate serious health problems have not been assessed Flynn,! Increase in the form of supplements is just too high 2000 mcg daily H. and Yvette Sheline!
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